Endocrine Abstracts

Background: Several criteria (i.e., cortisol supprimibility after 1 mg overnight dexamethasone suppression test -F-dex-, low ACTH levels, high 24 h urinary free cortisol levels -UFC-, high midnight serum cortisol levels) have been used for defining SH. Nevertheless, a real gold standard combination of tests is lacking. Recently midnight salivary cortisol (MSC) has been described as a sensitive marker for the diagnosis of overt hypercortisolism, while the role of MSC in the dia...

In the last years an increasing incidence of cardiovascular diseases (CVD) has been reported in young adults (18-45 yrs), probably accounted by the significant increase in CV risk (CVR) factors. Observational and interventional studies, mainly focused on middle-aged and elderly men, demonstrated that metabolic CVR (mCVR) factors and CVD manifestations are common in hypogonadal men and, conversely, testosterone deficiency is highly prevalent in metabolic disorders; the lack of ...

Campania Region has been facing waste management crisis since 1980, characterized by urban, toxic and industrial waste illegal disposal, burying and incineration. Cadmium (Cd) is consistently shown to affect male reproductive function by multiple mechanisms, mostly elucidated in experimental models. The aim of the current single-center, observational, cross-sectional cohort study was to evaluate the prevalence of testis morphostructural alterations in a large cohort of men liv...

Introduction: The need of a long-term follow-up in adrenal incidentalomas (AI) is debated and data on cardiovascular events (CVE) are lacking.Methods: In this retrospective study all patients referred to seven Italian Endocrine Centers for AI, without signs of hypercortisolism at baseline and with a ≥5 years follow-up (80.7±30 months, range 60–286), were enrolled. From 171 patients (121 F) aged 59.5±10.2 years (range 25–79) the ...

The fracture risk in primary hyperparathyroidism (PHPT) is partially independent of bone mineral density (BMD) and seems to depend on decreased bone quality, which is still reliably assessed only with invasive techniques. Trabecular bone score (TBS) is a grey-level texture measurement acquired during a dual X-ray absorptiometry (DXA) lumbar spine scan and it has been recently proposed as index of bone quality. This study is aimed to assess the role of TBS in predictin...